Oncothermia in Combination with Vitamin C Infusion for Non-small Cell Lung Cancer: a Case Report

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Summary

A patient was referred for coughing and hemoptysis. He had a medical history of diabetes and smoked two packs a day for many years but quit three years before he was diagnosed with Non-small Cell Lung Cancer. The case was considered inoperable and the patient refused chemotherapy and radiotherapy. The approach was to use Vitamin C IV in combination with modulated electro-hyperthermia (Oncothermia). As a result Oncothermia combined with Vitamin C infusion is safe and shows a favorable outcome and improved the the quality of life for the patient.

Introduction

A 69-year-old man was referred 6 years ago for coughing and hemoptysis. A chest computed tomography (CT) scan revealed a solitary pulmonary nodule in the left upper lobe, enlarged lymph nodes in the supraclavicular fossa, mediastinum and pericardial effusion, and left pleural effusion. A fiber-optic bronchoscopy was performed, and the pathology report indicated moderately differentiated squamous cell carcinoma of the left lung.
A physical examination revealed a barrel chest, thoracic symmetry, and disappearance of left lung breath sounds. The Karnofsky score was 80. The patient’s height was 1.65 m, weight was 51 kg, and body mass index (BMI) was 18.73. The Patient-Generated Subjective Global Assessment (PG-SGA) score was 5.

The final diagnosis was left lung squamous cell carcinoma with multiple lymph node metastasis (T3N3M0, Stage IIIB) and chronic obstructive pneumonia. His medical history included hypertension and a history of diabetes for many years. He had also smoked two packs a day for many years but quit smoking three years before the disease was diagnosed. The case was considered to be inoperable, and the patient refused to undergo chemotherapy and radiotherapy.

Methodology

Administration of Vitamin C IV in combination with modulated electro-hyperthermia (Oncothermia) from October 2010 to April 2011. The patient received Vitamin C at 1g/kg at a rate of 0.5 g/min. The treatment was administered 3 times a week for a total of 25 infusions and was given simultaneously with mEHT.

Treatment

The mEHT was administered as 60 min/session, 3 times a week, for 8 weeks, for a total of 25 sessions from 2010 to 2014. The power of mEHT was gradually increased from 135 W to 150 W based on the patient’s actual tolerance. The applicator used was 7.1 dm2. The applied energy range in one session was between 486 KJ and 540 KJ.

Results

The tumor size was measured by chest CT scans after each treatment cycle (25 treatments). The tumor shrank by nearly 50% after the first treatment cycle. The patient is followed for 5 years; the treatments greatly improved his quality of life, and he remains well with no evidence ofprogression in the lung mass (so far, he has survived 61 months). He experienced no adverse events attributable to oncothermia or Vitamin C infusion.
His hemoptysis disappeared after 12 treatments. The patient gained 3 kg and the Karnofsky score increased to 100 points one month after the completion of 25 sessions of treatment. The PG-SGA score decreased to 2. A subsequent CT scan suggested that the left upper lobe consolidation was reduced, and the tumor had shrunk slightly in April 2011.

The patient continued to receive Vitamin C IV and oncothermia for another 30 sessions of treatment from April 2011 to April 2012. The coughing and hemoptysis had both disappeared after completion of the treatments. One month after completion of the treatments, the CT scan showed re-expansion of the previously collapsed left upper lobe, and the tumor size had further decreased in April 2012 in comparison with the 2011 scan. The patient felt well and did not return for any treatments in 2013. However, he complained of cough and shortness of breath and returned in March 2014.
A CT scan was performed at that time, and it was observed that there was an abrupt truncation of a bronchus from an obstruction of the left upper lobe, compensatory emphysema of the right lung, and an increase in the tumor size by 10 mm and the left lung tumor lesions had increased, with a small amount of pleural effusion in the left lung.

The patient was administered another 40 sessions of Vitamin C infusion in combination with oncothermia using the same protocol. All symptoms were relieved after 20 sessions of treatment. A subsequent CT scan suggested that the atelectasis and obstructive pneumonia were improved, and that the tumor size had shrunk, with the pleural effusion disappearing in July 2014. He received Vitamin C infusion and oncothermia for a total of 25 sessions in 2015. The treatments greatly improved his quality of life, and he remains well at present (61 months).

Conclusion

This shows that oncothermia in combination with Vitamin C infusion is safe and shows a favorable outcome and improved the quality of life of the patient with non-small cell lung cancer.

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Scientific article publishing date : 15/8/2019

Immucura identifier : BSC21_053EN

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