Nanothermia / mEHT

Advanced Hyperthermia to support Cancer Therapy

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What is Nanothermia?

The mission of Nanothermia, or modulated electro-hyperthermia (mEHT), is to heal cancer, increase life expectancy and improve the quality of life of the patients with cancer. Modulated electro-hyperthermia (mEHT) is a complementary antitumor therapy applying capacitive radiofrequency at 13.56 MHz. It is a personalized, non-toxic therapy using an electric field and promoting the body’s natural regulatory processes.

Unlike conventional HT, however, mEHT does more than simply warm deep layers of tissue or function solely via certain thermodynamic parameters like temperature, it also combines such warming with a modulated electric field, generated by two active electrodes. Micro-biological tests have proven that malignant tissue has higher conductivity than healthy human tissue.

How does Nanothermia / mEHT work?

As a result, mEHT selectively destroys malignant cells by applying the required specific energy dose, inhibiting the natural activity of malignant cells, as well as triggering and supporting the body‘s immune response. When this therapy is combined with dendritic cell therapy (DCT), the effect of both improves considerably, since their effects are mutually beneficial.

The special feature of mEHT is that it promotes the renewal of cell junctions (e.g. E-cadherin and βß-catenin junctions), thereby facilitating the natural cell death process (apoptosis). Apoptosis is an orderly process in which the cell’s contents are packaged into small packets of membrane for “garbage collection” by immune cells.

Why meHT / Nanothermia is better than conventional Hyperthermia:

  1. Conductive heating vs. focusing heating
  2. Healthy tissue temperature increases only slightly
  3. Tumour temperature stays below the cytotoxic range (>42°C)
  4. Instruction of the immune cells
  5. Induces Apoptosis resulting in natural cell death process

Effects of Nanothermia / mEHT

mEHT selects at the cellular level, being malignant cells selectively destroyed. The selection occurs as a result of special metabolic characteristics of malignant cells. The special feature of mEHT is that it promotes renewed formation of cell connections (E-cadherin and βß-catenin junctions), thereby facilitating the apoptosis. Cell scattering is reduced, and apoptosis is initiated via delocalization of β-catenin and activation of the tumour-suppressor protein p53.

The tumour suppressor p53 protein plays an important role in cell-cycle regulation, and its inactivating mutations are pivotal to tumorigenesis in many human malignancies.

Benefits of Nanothermia / mEHT

• Painless and free of side effects
• Stimulation of the immune system
• Activation of the p53 tumour suppressor gene
• Acidic poisoning of the malignant tissue
• Used in postsurgical setting to treat potential cells liberated
• Focuses automatically on tumour tissue
• Thermal damage of tumour cells
• Synergetic effects with DCT
• Potentiation of chemo- and radiotherapy
• Significant gain of life-quality
• Inhibition of repair mechanism

Numerous clinical studies have been carried out on the effect of Nanothermia:

TO THE STUDIES >

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