Category: Glioblastoma

MGMT Methylated

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma MGMT Methylated Contact Us Summary This trial aims to evaluate the addition of an autologous tumor lysate-pulsed Dendritic Cell vaccine (DCVax®-L) to standard therapy for patients diagnosed with glioblastoma. The findings suggest the addition […]

Clinical study on Malignant Astrocytoma

Dendritic Cell Vaccine trial for Malignant Astrocytoma: potential interaction with adjuvant Chemotherapy

Dendritic Cell Vaccine trial for Malignant Astrocytoma: potential interaction with adjuvant Chemotherapy Clinical study on Malignant Astrocytoma Contact Us Summary Dendritic cell vaccination has been applied to the treatment of a variety of cancers, including malignant astrocytoma. In this study, 13 patients with malignant astrocytoma using dendritic cell vaccination were treated and have shown that […]

PFS for Adult Patienbts

Postoperative Adjuvant Dendritic Cell Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme

Postoperative Adjuvant Dendritic Cell Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme Contact Us Summary The aim of this study is to investigate the therapeutic role of adjuvant vaccination with autologous mature dendritic cells (DC) loaded with tumour lysates derived from autologous, resected glioblastoma multiforme (GBM) at time of relapse. The results suggest that the […]

T-Cell obtained from CFS

Immune response generated with the administration of autologous Dendritic Cells pulsed with an allogenic Tumoral Cell- lines lysate in patients with newly diagnosed diffuse intrinsic pontine glioma

Immune response generated with the administration of autologous Dendritic Cells pulsed with an allogenic Tumoral Cell- lines lysate in patients with newly diagnosed diffuse intrinsic pontine glioma Contact Us Summary This trial demonstrates the use of autologous dendritic cells (ADCs) pulsed with an allogeneic tumors cell-lines lysate in patients with newly diagnosed diffuse intrinsic pontine […]

MRI Scan

Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study

Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study Contact Us Summary DC loaded with proteins derived from autologous tumour homogenate is used for the treatment of patients with relapsed malignant glioma. As a result the approach may prolong survival of patients with malignant brain tumours without compromising […]

Progression-free survival

Adjuvant Dendritic Cell-Based Tumour Vaccination for Children With Malignant Brain Tumours

Adjuvant Dendritic Cell-Based Tumour Vaccination for Children With Malignant Brain Tumours Contact Us Summary The study focuses on the results obtained in children with relapsed malignant brain tumours. the results primarily are promising and support further testing of DC-based immunotherapy in new treatment protocols for high grade glioma and Atypical Teratoid Rhabdoid Tumor. Patients characteristics […]

Magnetic resonance imaging of glioblastoma

Modulated Electro-hyperthermia in Integrative Cancer Treatment for Relapsed Malignant Glioblastoma and Astrocytoma- Retrospective Multicenter Controlled Study

Modulated Electro-hyperthermia in Integrative Cancer Treatment for Relapsed Malignant Glioblastoma and Astrocytoma- Retrospective Multicenter Controlled Study Contact Us Summary The study aims to evaluate the safety and efficacy of modulated electrohyperthermia (mEHT) to treat relapsed malignant glioma and astrocytoma versus. The therapy may have a promising role in the treatment and palliation of relapsed GBM […]

Overall Survival

Autologous Dendritic Cell Vaccination and Radiochemotherapy following Fluorescence-guided Surgery in Newly Diagnosed Glioblastoma Patients

Autologous Dendritic Cell Vaccination and Radiochemotherapy following Fluorescence-guided Surgery in Newly Diagnosed Glioblastoma Patients Contact Us Summary This study investigates the combination of tumor lysate-pulsed autologous dendritic cells (DCs) vaccination to maximal safe resection with radiotherapy on patients diagnosed with Glioblastoma to improve patients survival. The findings suggest that the combination of f tumor lysate-pulsed […]

Treatment Scheme

Phase III randomized trial of autologous cytokine-induced killer cell immunotherapy for newly diagnosed glioblastoma in korea

Phase III randomized trial of autologous cytokine-induced killer cell immunotherapy for newly diagnosed glioblastoma in korea Contact Us Summary The study aims to evaluate the efficacy and safety of CIK cell immunotherapy with radiotherapy-temozolomide (TMZ) for the treatment of patients with glioblastoma. The addition of CIK cells immunotherapy to standard chemoradiotherapy with TMZ improved PFS. […]

Treatment Scheme

A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma

A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma Contact Us Summary This study focuses on the effects of an autologous Dendritic Cell vaccine pulsed with six synthetic peptide epitopes for glioblastoma (GBM). The vaccine was well tolerated and increased progression-free survival by 2.2 months while […]