Cytolytic Immunity of CIK cells upon Coculture with Mature Dendritic Cells
Results of the treatment
Summary
Dendritic cells (DCs) are considered the most potent professional antigen-presenting cells (APCs) that elicit adaptive antitumour immunity. In this study several methods of boosting DC-based vaccines are discussed and a review of the current knowledge of contact-dependent and cytokine-induced interactions of mo-DCs with CIK cells is done. We highlight that the combination of mo-DCs with CIK cells activates MHC-restricted and MHCunrestricted immune responses. This review reveals the role of both contact-dependent activation of CIK cells and the cytokine-dependent cytolytic capacity of CIK cells upon coculture with mature DCs.
Introduction
The crosstalk between dendritic cells, cytokine-induced killer cells and cancer cells from the perspective of combination therapy.
Methodology
In this review, we will discuss the role of contact-dependent activation and cytokine-dependant cytolytic capacity of CIK cells upon coculture with mature DCs. We will start by explaining DC’s importance in immunity and how they can be used for therapeutic purposes. Next, we will focus on the different types of CIK cell subsets and their roles in dct. Finally, we conclude by discussing what kind of future research is needed to better understand the interaction between these two cells populations.
Treatment
The possibility of overcoming tumour-related immunosuppression due to the enhanced cytotoxicity and proliferation of CIK cells after coculture with in vitro-modified DCs makes such combination therapy an attractive immunomodulatory approach for the induction of anticancer immune responses.
Conclusion
Dendritic cells have been investigated for their ability to stimulate cytotoxic T-cells in the treatment of cancer. This review revealed the role of both contact-dependent activation of CIK cells (involving CCR5 signalling) and the cytokine-dependent cytolytic capacity of CIK cells upon coculture with mature DCs. Overall, these data are encouraging for dct therapies involving co-culture with mature DCs.